A powerful new foundation for custom queries—built on Lucene and designed for R&D precision.

Over the past few years, Cypris has helped innovation teams make faster, more informed decisions by centralizing critical insights across datasets like patents, academic papers, and company activity. But until now, our search experience relied on a legacy query system with limited capabilities, offering little support for advanced search features or dataset-level customization.

Today, we’re excited to introduce an upgraded Advanced Search on Cypris, a complete overhaul of our query engine and search experience, powered by the open-standard Lucene query syntax. This update introduces a more robust and flexible search foundation, unlocking new ways to query data, build complex filters, and extract precisely what you need across patents, research, and more.

Why we rebuilt our search system from the ground up

Cypris’ original query syntax, a proprietary format used internally for years, limited users’ ability to craft advanced queries or tailor searches to specific datasets. It lacked modern capabilities like proximity searches, field-level customization, or true Boolean logic. This made it difficult to build a reliable and intuitive experience for both casual users and advanced researchers.

By moving to Lucene, we’re adopting a powerful, industry-standard query language that makes it easier for developers to build advanced features—and gives users access to a far more capable and flexible search toolset.

What’s new in Advanced Search

1. Custom Queries by Dataset
You can now layer queries to search across datasets or tailor filters to each one. For example, you can run a broad query on drone delivery, and then add separate layers to focus on patents by a specific assignee and papers from a specific country or funding agency.

Navigating the All Datasets tab introduces a new level of complexity—and power—by allowing users to apply dataset-specific logic within a single, unified query workflow. While querying multiple datasets simultaneously might seem straightforward, the underlying differences in schema, metadata, and available fields between our proprietary datasets make this a deeply technical challenge. Patents, for example, include claims, application numbers, and multiple date fields (filed, granted, updated), while academic papers use DOIs, have different structural conventions, and emphasize different metadata. In the past, we sidestepped this complexity by translating general queries like ((drone_allText)) into dataset-specific logic under the hood. Now, instead of obscuring that logic, we allow users to opt in to it. The builder provides progressive layers of customization: start with intuitive keyword searches across all fields, then move into the advanced builder for field-specific targeting, fuzzy logic, and term boosting, and finally, tailor query logic by dataset—such as specifying different countries of interest for papers vs. patents. This approach preserves flexibility while giving users full control, and with tools like our real-time Live Analysis and “Your Query” panel, we make it easy to understand how every decision affects the results.

2. More Fields to Query
We’re exposing deeper fields across datasets—giving you explicit control over the dimensions of your search. For the first time, users can now search academic papers by DOI, a critical identifier previously unsupported on the platform. You can also query by:

- Author or inventor names

- Organizations or assignees

- Countries, journals, funding agencies, and more

3. Full Boolean Support
Advanced Search now leverages powerful Boolean logic—AND, OR, NOT, and grouping—enabling more precise control over search logic and improving performance and accuracy.

4. Lucene Syntax Features
Use built-in Lucene features to create expressive, complex searches:

- Proximity searches to find terms near each other

- Fuzzy searches for flexible matching

- Exact phrase matching

- Boosting to prioritize results (e.g., prioritize results mentioning AI 3x more than others)

- Prefix/Postfix queries to match phrases that start or end a certain way

- Range queries for fields like date, funding amounts, or numerical values

A more powerful user experience

Our new search interface is built to help you tap into these capabilities without needing to know the syntax from the start. You’ll find:

- A Query Builder to guide you through complex searches

- A Help Video to onboard users to Lucene-style searches

- Inline examples and tips for writing queries using grouping, boosting, and more

Built for precision, speed, and customization

With Lucene as our foundation, search results are now not only more flexible but also faster and more accurate. Semantic search continues to offer natural-language ease of use, while Boolean search gives power users the performance and structure they need to uncover insights with greater specificity.

Whether you’re an innovation analyst drilling into AI patents or a business development lead scanning academic papers from Chilean researchers—Advanced Search is built to help you get to the signal, faster.

Available now to all users

Advanced Search is live and available across the Cypris platform today. If you’re already using Cypris, you’ll find the new search interface in your dashboard, complete with updated syntax documentation and walkthroughs.

We’re excited to see what you’ll build, discover, and analyze with this new capability. This is just the beginning—we’ll continue expanding the fields, syntax features, and customization options as we push the boundaries of what intelligent search can do for R&D.

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Today, the need for society to adopt sustainable practices is increasingly urgent, particularly in chemical manufacturing, which is responsible for greenhouse gas emissions, toxic waste, increased water and energy consumption, and inefficient raw material use. Consequently, the market for sustainable chemical manufacturing has surged to $10 billion and continues to expand as the focus on sustainability intensifies. Leading this charge are three innovative approaches: mechanochemistry, green synthesis, and microflow chemistry. Mechanochemistry, which induces chemical reactions through mechanical energy, accelerates reactions and conserves energy compared to traditional solvent-based methods, while reducing reaction mass and potentially increasing product yield by avoiding solvents. Green synthesis aims to minimize the use and generation of hazardous substances, thereby reducing environmental impact and enhancing sustainability, with notable examples including the synthesis of spirooxindole derivatives using heterogeneous catalysis and metal-organic framework (MOF) catalysts. Microflow chemistry, or continuous flow chemistry, involves reactions in microreactors that allow precise control over reaction conditions, enhancing safety, scalability, and efficiency. The integration of these three approaches—mechanochemistry, green synthesis, and microflow chemistry—represents a significant advancement in sustainable chemical manufacturing, addressing critical challenges from waste reduction to energy savings and paving the way for a more sustainable industry.

Mechanochemistry: Mechanochemistry accelerates reactions and reduces solvent use, advancing sustainability in chemical manufacturing.

Mechanochemistry, a process in which chemical synthesis is induced by external mechanical energy, has gained attention in chemical manufacturing due to its sustainable nature. This method allows reactions to occur more quickly and saves energy compared to traditional solvent-based chemistry. Mechanochemistry also offers cost and time efficiency by eliminating the need for solvents, thereby reducing 90% of the reaction mass, and potentially increasing product yield under optimal conditions. 

The disposal of plastics, which are non-biodegradable and create significant pollution, is a growing concern for the health and longevity of the planet. Recently, research has focused on using mechanochemistry to control the degradation of polymers found in plastics. Researchers have discovered that the previously separate fields of polymer and trituration mechanochemistry can converge, enabling the degradation of polymers through milling and grinding. This breakthrough holds the potential to significantly mitigate global warming.

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Green Synthesis: Green synthesis reduces hazards and waste with efficient methods like heterogeneous and MOF catalysts.

Green synthesis involves creating chemical products and processes that minimize the use and production of hazardous substances, aiming to reduce environmental impact and enhance sustainability in chemical manufacturing. This approach not only benefits the environment but also protects the health and safety of chemical workers and consumers, while reducing costs associated with waste disposal and raw material use.

Spirooxindole has been a focus in the green synthesis field due to its broad benefits in medicine as well as agriculture because of it being a unique compound because of the high reactivity of the carbonyl group located at the 3-position of isatin. Various green synthesis methods have been used for creating spirooxindole derivatives. Various green synthesis methods have been developed for creating spirooxindole derivatives, with one promising approach being the use of heterogeneous catalysts. These catalysts, which are in different phases from the reactants and products, allow for effortless separation, minimizing waste, shortening processing time, and conserving energy.

Another promising method in green synthesis is the use of metal-organic framework (MOF) catalysts. MOFs are attractive due to their high surface area, large porosity, multiple catalytic sites, and highly tunable composition and structure. Studies have shown that MOF catalysts can achieve high yields of 95%-99% and short reaction times. For example, Mirhosseini-Eshkevari et al. (2019) synthesized a zirconium metal-organic framework (Zr MOF) called TEDA/IMIZ-BAIL@UiO-66 using benzene dicarboxylic acid as the organic linker. This framework served as a heterogeneous catalyst in the synthesis of spirooxindole derivatives, with the BAIL@UiO-66 catalyst acting as a Brønsted acid to enhance the electrophilicity of the carbonyl group in isatin and promote nucleophilic attack. This catalyst can be reused in other reactions with minimal reduction in yield, demonstrating its potential as a promising alternative to non-renewable processes.

Microflow Chemistry: Microflow chemistry boosts efficiency and sustainability with precise control and effective processing of renewable resources and waste.

Microflow chemistry, also known as continuous flow chemistry or microfluidic chemistry, is highly regarded for its efficiency, safety, and sustainability in chemical manufacturing. This approach involves chemical reactions occurring in microreactors, which allow for precise control over reaction conditions, thereby enhancing safety, scalability, and efficiency. Microflow chemistry is utilized in various fields, including environmental science, fine chemicals, materials science, and pharmaceuticals.

Recently, microflow chemistry has proven sustainable not only due to its efficient process but also because of its applications. It is now central to green catalytic engineering for processing renewable resources. For instance, microflow chemistry is used to process lignocellulosic biomass into fuels and chemicals. Lignocellulose, found in the microfibrils of plant cell walls and composed mainly of polysaccharides and lignins, has been extensively studied for this purpose. Microflow chemistry is highly favored for this process due to its enhanced product yield and selectivity.

Furthermore, microflow chemistry improves sustainability in on-site chemical manufacturing. Biomass, which contains a significant amount of water, requires considerable energy for transportation to refineries, making onsite processing essential. This is also true for food waste, which has a short shelf life and is produced in large quantities. Even plastic waste, despite its longevity and low water content, is widespread in landfills and ecosystems, necessitating onsite processing in remote and offshore areas. Microflow chemistry offers better economic viability and higher energy efficiency, supporting sustainable onsite manufacturing.

The crucial shift towards sustainable practices in chemical manufacturing is driven by the environmental and societal challenges posed by traditional methods. Innovations like mechanochemistry, green synthesis, and microflow chemistry are at the forefront of this transformation. Mechanochemistry accelerates reactions while minimizing solvent use, promising reduced energy consumption and waste generation. Green synthesis techniques, utilizing heterogeneous catalysis and metal-organic frameworks, provide efficient, low-impact pathways to valuable compounds like spirooxindoles, essential in medicine and agriculture. Microflow chemistry, with its precision in controlling reaction conditions, enhances safety and efficiency, especially in processing renewable biomass and managing onsite waste such as food and plastic. Together, these approaches not only reduce environmental impacts, including greenhouse gas emissions and toxic waste, but also promote a more resilient and sustainable chemical industry, ready to meet future challenges.

Over the past five years, significant advancements in wearable medical devices have greatly enhanced patient care by offering convenience, personalized healthcare, and improved engagement through continuous monitoring. These devices provide real-time healthcare data, potentially saving the global healthcare sector $200 billion over the next 25 years, with a market expected to reach $29.6 billion by 2026. Complementing traditional medical instruments, wearable devices enable continuous biomarker monitoring, unlike invasive and intermittent blood sampling methods. Innovations in e-textiles provide comfort and biosensing capabilities, supporting real-time health data monitoring and communication. Continued research in biosensing and drug delivery systems, such as microscale and hydrogel-based devices, promises further improvements in accuracy, convenience, and patient outcomes.

E-Textiles: The Future of WDDs 

E-textiles have emerged as a crucial component of wearable technology, addressing challenges associated with traditional materials used in wearable medical devices. Traditional materials often lack comfort, reusability, and long-term wear potential. E-textiles overcome these issues by offering comfort, biosensing features, and extended service life, significantly enhancing patient comfort and the effectiveness of wearable technology. They provide a platform for various technologies to monitor patient health, enabling point-of-care outside hospital environments.

E-textiles facilitate wireless connections with different devices and systems, enabling information transfer through technologies like near-field magnetic induction, far-field radiation, and ultrasonic arrays. Additionally, RFID and Bluetooth support data collection and transmission, while near-field inductive technology allows efficient power transfer without close contact. These advancements enable real-time monitoring and statistical analysis of health data, crucial for healthcare providers to deliver appropriate therapies. Wireless connections, leveraging sources such as ZigBee, Bluetooth Low Energy, and 5G, contribute to low-power connectivity, cost-effectiveness, and real-time communication between patients and healthcare providers.

Despite these advancements, challenges remain in realizing the full potential of e-textiles in patient care. Energy efficiency issues persist due to high power consumption required for wireless communication sources, and integrating circuit chips into textiles for wireless communication modules remains complex. Continued research and innovation in e-textiles are essential to improve energy efficiency and simplify the embedding process, enhancing continuous monitoring capabilities for healthcare providers and patients.

Advanced Drug Delivery in WDDs: Microscale and hydrogel devices improve drug delivery

Wearable medical devices for drug delivery have also seen exciting developments, enhancing accuracy and convenience while minimizing systemic side effects. Microscale devices, such as microtubes, micropumps, and microneedles, offer non-invasive drug delivery with high measurement accuracy and sensitivity. These devices are expected to reduce the limitations of wearable drug delivery devices (WDDs), making them versatile carriers for various drugs, peptides, and vaccines.

Hydrogels are another promising component of WDDs due to their structural similarity to the natural extracellular matrix and excellent biocompatibility. However, traditional hydrogels have limitations in treating complex diseases. To address this, innovations have focused on enhancing hydrogel conductivity using conductive polymer-based materials like PEDOT and PANI, ensuring drug efficacy while providing conductivity. Soft hydrogels are being explored for on-demand drug delivery, acting as nano-drug reservoirs and releasing drugs from thermally responsive hydrogels when a flexible heater is embedded in the conductive gel.

Despite these advancements, further research is needed to overcome issues such as component separation, which affects the durability of therapeutic electronic skins. Solutions like self-assembly surface modification, UV-induced polymerization, and dispersion adhesives are being investigated to improve the connection between hydrogels and various devices. Continuous innovation in this field is essential to fully realize the potential of wearable medical devices to enhance ease and health outcomes in patients' lives.

Biosensing Breakthroughs in Wearable Medical Tech: Wearable biosensors allow for personalized healthcare through monitoring

Biosensing technology has also seen significant innovations within wearable devices, enabling the detection and monitoring of various health issues. A notable example is a smart contact lens that can detect physiological conditions through tear fluid samples. Tear fluid is particularly valuable for biosensing due to its accessibility, similarity to blood, and the range of detectable diseases through metabolites, proteins, and cytokines. Diseases that can be detected include breast cancer, diabetes, Parkinson's disease, and glaucoma. Continuous glucose monitors for diabetics are another example, allowing patients to monitor their glucose levels continuously and understand the causes behind fluctuations. This technology reduces the need for painful finger-prick tests, lowering the risk of infection and improving patient quality of life.

‍The Rapid Growth and Importance of WDDs 

The wearable medical device industry has made remarkable progress in recent years, offering numerous benefits to patients and healthcare providers. Currently, at least 115 companies and 80 key industry players are expanding the applications of wearable healthcare devices, illustrating rapid growth and interest in this field. From continuous monitoring and personalized healthcare to innovative drug delivery systems and biosensing technologies, these devices are transforming healthcare delivery. While challenges remain, ongoing research and development hold the promise of further enhancing the capabilities and effectiveness of wearable medical devices, ultimately improving patient outcomes and quality of life.

Utilizing Cypris’ Innovation Dashboard, this blog was crafted to provide access to top-tier market data and AI insights on the latest innovation trends. By offering a comprehensive view of companies, startups, and universities' innovation activities, Cypris ensures access to critical information essential for understanding specific markets and advancing research and development initiatives. Get started now and unlock the insights you need to drive strategic decisions forward.